Fish Oils Block Prostate Cancer

Oily fish contain omega3 fats.A diet rich in a fat found in oily fish and some seeds may protect men with prostate cancer from developing a more aggressive form, scientists have found.
Prostate cancer is much more likely to be life-threatening if tumour cells migrate and invade other tissues, such as the bone marrow.
Lab tests found omega-3 oil – present in fish like salmon – prevented this.
The results of the study, based at Manchester’s Christie Hospital, are in the British Journal of Cancer.

Eating a diet with the right balance of omega-3 and omega-6 fats may well help to keep prostate cancer within the prostate gland
Noel Clarke

The Paterson Institute researchers tested the effect of two types of dietary fat on prostate cancer cells in the lab.
Previous research has suggested omega-3 fats, which is also found in some plant sources such as pumpkin seeds, may help cut the risk of cancer – and other conditions, such as heart disease.
Omega-6 fats, found in vegetable oils, nuts and seeds, also play a key role in keeping us healthy.
Energy source

However, while omega-6 fats increased the spread of prostate cancer cells into bone marrow, omega-3 fats blocked this.
Researcher Dr Mick Brown said: “It is possible to have a healthy balance of these two types of fat – we only need about half as much omega-3 as omega-6 – that will still stop cancer cells from spreading.”
The researchers believe tumour cells might use omega-6 fats as a high energy source – giving them the energy they need to maintain a high growth rate and to create molecules that control migration.
Omega 3 fats appear to interfere with this process in some way.
Lead researcher Noel Clarke said: “Some tumours develop slowly in the prostate without producing symptoms and sometimes when symptoms do develop, it is because the cancer has already spread.
“Eating a diet with the right balance of omega-3 and omega-6 fats may well help to keep prostate cancer within the prostate gland where it may be monitored safely or more easily treated with surgery or radiotherapy.”
Larger studies

Derek Napier, of the Association for International Cancer Research, which part-funded the study, said the findings might aid the development of new ways to block the spread of many types of cancer.
Professor John Toy, of Cancer Research UK, said the work was still at an early stage.
“We would need large population studies to provide the needed evidence to say a change in diet could reduce prostate cancer cells from spreading,” he added.
Prostate cancer is the most common male cancer in the UK.
The research was funded by the Association for International Cancer Research (AICR) and the Medical Research Council (MRC).
The Food Standards Agency recommends men can eat up to four portions of oily fish a week.

Alfalfa: A Continued Interest in its Believed Health Properties

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Within the nutritional supplements and natural products industry, alfalfa is being made available to consumers for dietary and preventative health care more and more as health reporting over the internet increases and its benefits become widely appreciated. Though not backed up by hard clinical evidence in humans, alfalfa is said to reduce cholesterol and blood sugar levels, promote liver health, detoxify the body, relieve pain and stiffness of arthritis/bursitis, and even alleviate postmenopausal “hot flashes”.

Alfalfa Complex
Deeply Rooted Nutrition: As a product and a plant, alfalfa has deep roots. Alfalfa Complex, developed in the 1950s, was one of Dr. Shaklee’s original formulations. A half a century later, it continues to be among Shaklee’s top sellers.

Named both the “King of Plants” and the “Queen of Forages”, alfalfa is thought to be the oldest cultivated forage crop in the US, and one of the most nutritious. If cut before it blooms, alfalfa is low in fiber and high in energy. That is why, beyond its nutritional potential for humans, alfalfa is valued as a principal component in dairy cattle rations and as feed for horses, beef cattle, sheep, and milking goats. Moreover, the plant offers distinct ecological benefits because of its very high yield potential compared with other forage crops, and it serves as an integral component of many crop rotations because of its ability to improve soil structure and condition, and control weeds in subsequent crop rotations.
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Osteoarthritis Risks and Possible Remedies

A New York Times Personal Health article dated July 30, 2002 reported that nearly 21 million Americans have at last some unwelcome familiarity with the pain of osteoarthritis. This leading cause of life-changing disability can only become more acute as the ranks of the elderly population swell to include the “baby boomers.”
Basically what happens is the following: The articular cartilage that exists in every joint in your body is there to provide an efficient, gliding surface to cushion the impact between the bones that form the joints as you move around and exert yourself. However, this cartilage loses its suppleness as time goes on until the synovium – the tissue that lines the joints – can become inflamed and wear thin. The bones can then become misshapen in the absence of lubrication resulting in long-term damage.
Several studies related to this condition have been published in the medical literature, according to Stephen E. Straus, M.D., National Director for Complementary and Alternative Medicine (NCCAM). “Those short-term, controlled clinical trials suggest that glucosamine is effective in relieving pain and increasing the range of motion in patients with osteoarthritis.”
Benefits of preventative care including dietary supplementation

  • Physical therapy to help increase muscle strength that supports joints with emphasis on how to minimize joint stress.
  • Regular aerobic exercises and swimming can help reduce the pain of osteoarthritis. Both activities increase much needed circulation in the joints that is often lost because sufferers tend to unnecessarily limit their physical activities.
  • Calcium supplements can be of particular benefit
  • Glucosamine – This is an amino-sugar naturally produced in humans and is the foundation of many of the body’s tissues, including tendons, ligaments, cartilage, collagen, and membranes in the respiratory tract and synovial fluid in the joints.
  • Devil’s Claw – A herb which has reportedly been helpful in promoting joint mobility and reducing pain and swelling.
  • The New York Times report cited above refers to research suggesting that vitamins C and D and possibly E may have a protective effect on the bones.

The Dangers of Trans-Fatty Acids and Heart Problems

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Recent press articles have reported that fat is closely tied to heart problems and is unsafe at virtually any level. Scientists argue that a strong link exists between what are called “transfats” and increased levels of LDL, the so-called “bad” cholesterol. Trans-fats develop during food preparation when liquid oils convert into semi-solids – and this happens not just in the fast food industry. Dairy products and beef, for instance, are also said to produce trans-fats naturally.
In light of numerous scientific studies on trans-fats and the adverse effects of high LDL levels in the body, the FDA has recently decided that it will require the declaration of trans fat content on food labels. However, no recommended daily limits will be identified due to lack of lack of consensus within the research community and the FDA on what limits are
acceptable. Essentially a zero consumption limit would be desirable but we know that this is a tall order considering the array of pastries, pizzas, french fries, cookies and other items on Americans’ daily menu.
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Osteoporosis in Post-Menopausal Women

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The recent spate of press reports on the abruptly discontinued clinical trial by the National Institute of Health and the Women’s Health Initiative which was examining the effects of the use of estrogen/progestin in women has generated media discussion on the closely related issue of osteoporosis and teeth and bone loss, especially as it impacts post-menopausal women disproportionally. Besides providing relief from hot flashes and night sweats, it was thought that estrogen/progestin could help alleviate a range of age-related conditions in women, including osteoporosis.
Roberto Civitelli, MD, of the Washington University School of Medicine in St. Louis, in a study published by the Archives of Internal Medicine, remarks, “The risk of tooth loss is higher for women aged 65 or older, and continues to increase the longer a woman has been post-menopausal.” He believes that the use of Vitamin D and calcium supplements are to be
strongly recommended whether or not a regimen of estrogen/progestin is concurrently taken.
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Coenzyme Q10 (CO-Q10)

An important, vitamin-like compound that is present throughout the body.
Coenzyme Q10 is an important, vitamin-like compound that is present throughout the body. While there are 10 other coenzyme Q compounds present in nature, Coenzyme Q10 is the only one present in humans. Although Coenzyme Q10 is widely used throughout Europe and Asia, its value is just beginning to be recognized in the United States for its support of cardiovascular health and more.

30 softgels / 30 servings
Coenzyme Q10 (CoQ10) supports energy production in your cells. The uniqueness of Shaklee CoQHeart comes from its highly bioavailable delivery. Your body more readily accepts the softgel delivery form used in CoQHeart than it does solid powders. So you can get more out of your supplement.

Coenzyme Q10’s benefits are due to the following two attributes. First, Co-Q10 is an important fat-soluble antioxidant that is uniquely able to protect the cells’ energy producing machinery, known as mitochondria, from free radical damage.(1) Second, Coenzyme Q10 is necessary for the production of energy in all cells of the body.
Even though Coenzyme Q10 occurs in the cells of all plants and animals, dietary sources do not provide adequate levels of this nutrient.
Reported Uses
Co-Q10 plays a vital role in the production of energy within the body’s cells. It also functions as a fat-soluble antioxidant. The most important application for Co-Q10, however, is in the treatment and prevention of cardiovascular disease and related disorders that involve the heart, including atherosclerosis.(2, 3, 4, 5) Studies have suggested that Co-Q10 can reduce the frequency of angina episodes, strengthen the heart muscle, and increase quality of life and survivability in those with congestive heart failure.(6, 7, 8, 9) Coenzyme Q10 has also been shown to decrease blood pressure in patients with high blood pressure.(10, 11)
Doctors have used Co-Q10 to treat breast cancer and support health in patients receiving chemotherapy.(12, 13) Of potential benefit to diabetics is the fact that Co-Q10 may enhance insulin production.(14) Co-Q10 has also been used with favorable results to treat symptoms of muscular dystrophy and gum disease, both of which are linked to Co-Q10 deficiency.(15, 16)
Laboratory studies indicate that patients with Parkinson’s disease may benefit from Co-Q10 supplementation.(17, 18, 19, 20) In fact, a human study involving 80 patients with early Parkinson’s disease, placed each in one of four groups; Co-Q10 300 milligrams per day (mg/d), Co-Q10 600 mg/d, Co-Q10 1,200 mg/d or in the placebo group. The researchers concluded that those receiving Co-Q10 developed less disability than those taking placebo.(21)
Obesity may also be linked to a deficiency of Co-Q10. Studies have suggested that supplementation can enhance weight loss(22) and it has been suggested that Co-Q10 could be beneficial in the treatment of patients with chronic fatigue syndrome.(23) In studies involving infertile men, Co-Q10 has been associated with an increase in sperm count,(24) improved sperm motility and improved rates of fertilization.(25) Also of important note is the fact that Co-Q10 may protect against the side effects of drugs such as beta-blockers and some antipsychotics. Ingestion of one or more drugs may interrupt the synthesis of Coenzyme Q10.(26)
Dosage Information
Dosage Range
30-300mg daily.
Most Common Dosage
30mg daily.
Dosage Forms
Softgel capsules containing CO-Q10 suspension in oil, powder-filled hardshell capsules, powder-based tablets, and liposomal sprays.
Toxicities & Precautions
Be sure to tell your pharmacist, doctor, or other health care providers about any dietary supplements you are taking. There may be a potential for interactions or side effects.
This dietary supplement is considered safe when used in accordance with proper dosing guidelines.
Health Conditions
If you have cardiovascular or heart disease talk to your doctor before taking this dietary supplement. Coenzyme Q10 strengthens the heart which can affect the dose and activity of the other medications you are taking for this health condition.(27) Reducing or discontinuing prescription medications for this condition must be supervised by your physician.
To date, the medical literature has not reported any adverse effects related to fetal development during pregnancy or to infants who are breast-fed. Yet little is known about the use of this dietary supplement while pregnant or breast-feeding. Therefore, it is recommended that you inform your healthcare practitioner of any dietary supplements you are using while pregnant or breast-feeding.
Age Limitations
To date, the medical literature has not reported any adverse effects specifically related to the use of this dietary supplement in children. Since young children may have undiagnosed allergies or medical conditions, this dietary supplement should not be used in children under 10 years of age unless recommended by a physician.

30 softgels / 30 servings
Coenzyme Q10 (CoQ10) supports energy production in your cells. The uniqueness of Shaklee CoQHeart comes from its highly bioavailable delivery. Your body more readily accepts the softgel delivery form used in CoQHeart than it does solid powders. So you can get more out of your supplement.

1 Sarkela TM. The modulation of oxygen radical production by nitric oxide in mitochondria. J Biol Chem. Mar2001;276(10):6945-9.
2 Oda T. Effect of Coenzyme Q10 on Stress-induced Cardiac Dysfunction in Paediatric Patients with Mitral Valve Prolapse: A Study by Stress Echocardiography. Drugs Exp Clin Res. 1985;11(8):557-76.
3 Mortensen SA, Leth A, Agner E, Rohde M. Dose-related decrease of serum Coenzyme Q10 during treatment with HMG-CoA reductase inhibitors. Mol Aspects Med. 1997;18 Suppl:S137-44.
4 Langsjoen PH, Langsjoen Am. Overview of the use of CoQ10 in cardiovascular disease. Biofactors. 1999;9(2-4):273-84.
5 Singh RB, Neki NS, Kartikey K, et al. Effect of Coenzyme Q10 on risk of atherosclerosis in patients with recent myocardial infarction. Mol Cell Biochem. Apr2003;246(1-2):75-82.
6 Kamikawa T, et al. Effects of Coenzyme Q10 on Exercise Tolerance in Chronic Stable Angina Pectoris. Am J Cardiol. Aug1985;56(4):247-51.
7 Sinatra ST. Coenzyme Q10: A Vital Therapeutic Nutrient for the Heart with Special Application in Congestive Heart Failure. Conn Med. Nov1997;61(11):707-11.
8 Langsjoen PH, et al. A Six-year Clinical Study of Therapy of Cardiomyopathy with Coenzyme Q10. Int J Tissue React. 1990;12(3):169-71.
9 Tran MT, Mitchell TM, Kennedy DT, Giles JT. Role of Coenzyme Q10 in chronic heart failure, angina, and hypertension. Pharmacotherapy. Jul2001;21(7):797-806.
10 Langsjoen P, et al. Treatment of Essential Hypertension with Coenzyme Q10. Mol Aspects Med. 1994;15(Suppl):S265-72.
11 Burke BE, Neuenschwander R, Olson RD. Randomized, double-blind, placebo-controlled trial of Coenzyme Q10 in isolated systolic hypertension. South Med J. Nov2001;94(11):1112-7.
12 Lockwood K, et al. Progress on therapy of Breast Cancer with Vitamin Q10 and the Regression of Metastases. Biochem Biophys Res Commun. Jul1995;212(1):172-77.
13 Tsubaki K, et al. Investigation of the Preventive Effect of CoQ10 against the Side-effects of Anthracycline Antineoplastic Agents. Gan To Kagaku Ryoho. Jul1984;11(7):1420-27.
14 Kishi T, et al. Inhibition of Myocardial Respiration by Psychotherapeutic Drugs and Prevention by Coenzyme Q10. In: Yamamura Y, Folkers K, Ito Y, eds. Biomedical and Clinical Aspects of Coenzyme Q10. Vol. 2. Amsterdam: Elsevier/North-Holland Biomedical Press;1980:139-54.
15 Folkers K, et al. Two Successful Double-blind Trials with Coenzyme Q10 (Vitamin Q10) on Muscular Dystrophies and Neurogenic Atrophies. Biochem Biophys Acta. May1995;1271(1):281-86.
16 Hansen IL, et al. Bioenergetics in Clinical Medicine. IX. Gingival and Leucocytic Deficiencies of Coenzyme Q10 in Patients with Periodontal Disease. Res Commun Chem Pathol Pharmacol. Aug1976;14(4):729-38.
17 Ebadi M, Govitrapong P, Sharma S, at al. Ubiquinone ( Coenzyme Q10) and mitochondria in oxidative stress of parkinson’s disease. Biol Signals Recept. May2001;10(3-4):224-53.
18 Shults CW, Haas RH, Beal MF. A possible role of Coenzyme Q10 in the etiology and treatment of Parkinson’s disease. Biofactors. 1999;9(2-4):267-72.
19 Muller T, Buttner T, Gholipour AF, Kuhn W. Coenzyme Q10 supplementation provides mild symptomatic benefit in patients with Parkinson’s disease. Neurosci Lett. May2003;341(3) 201-4.
20 Winkler-Stuck K, Wiedemann FR, Wallesch CW, Kunz WS. Effect of Coenzyme Q10 on the mitochondrial function of skin fibroblasts from Parkinson patients. J Neurol Sci. May2004;220(1-2):41-8.
21 Shults CW, Oakes D, Kieburtz K, Beal MF, Haas R, Plumb S, et al. Effects of Coenzyme Q10 in early Parkinson disease: evidence of slowing of the functional decline. Arch Neurol. Oct2002;59(10):1541-50.
22 van Gaal L, et al. Explatory Study of Coenzyme Q10 in Obesity. In: Folkers K, Yamamura Y, eds: Biomedical and Clinical Aspects of Coenzyme Q10. Vol 4. Amsterdam: Elsevier Science Publications; 1984:369-73.
23 Werbach MR. Nutritional strategies for treating chronic fatigue syndrome. Altern Med Rev. Apr2000;5(2):93-108.
24 Alleva R, Scararmucci A, Mantero F, et al. The protective role of ubiquinol-10 against formation of lipid hydroperoxides in human seminal fluid. Mol Aspects Med. 1997;18(Suppl):S221-8.
25 Lewin A, Lavon H. The effect of Coenzyme Q10 on sperm motility and function. Mol Aspects Med. 1997;18(Suppl):S213-9.
26 Rundek T, Naini A, Sacco R, Coates K, DiMauro S. Atorvastatin decreases the Coenzyme Q10 level in the blood of patients at risk for cardiovascular disease and stroke. Arch Neurol. Jun2004;61(6):889-92.
27 Langsjoen H, Langsjoen P, Langsjoen P, et al. Usefulness of Coenzyme Q10 in clinical cardiology: a long-term study. Mol Aspects Med. 1994;15(Suppl):s165-75.

Soy May Help Prevent Breast Cancer in Older Women

January 16, 2006
(The New York Times News Service) — A diet rich in soy, with its natural plant estrogens or isoflavones, may help protect postmenopausal women with relatively high levels of estrogen from getting breast cancer, preliminary research suggests.
Women past menopause who have low estrogen levels probably won’t derive the same risk reduction, but they can probably be assured the soy isn’t harmful in terms of breast cancer risk, said Charles E. Wood, an instructor of pathology at Wake Forest University.
“If you have high estrogen, the isoflavones could block the adverse effects of your body’s own estrogen (on the breast tissue),” said Wood, who based his views on his team’s study involving postmenopausal monkeys, published in the Jan. 15 issue of Cancer Research.

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Wood’s study adds new fuel to the ongoing debate surrounding soy’s effect on cancer risk. “There’s been a good deal of confusing information, particularly with soy’s effect on (breast) cancer risk,” said Wood.
“Most population-based studies have found that women who consume lots of soy are less likely to develop breast cancer,” he said. “A number of studies have been done, and they generally show a positive effect or no effect.”
But in lab studies, Wood said, isoflavones from soy — which have a structure similar to estrogen — have been found to stimulate breast cancer cells grown in a petri dish and induced estrogen-like effects.
“Our hypothesis was that the amount of estrogen in the body may help determine whether soy was having good or bad effects,” he said. “If you have very low estrogen, high doses of soy could have adverse estrogen-like effects on your reproductive tissue. If you had high estrogen, the isoflavones could block the adverse effects of your body’s own estrogen. That was our working hypothesis.”
Wood and his team used a postmenopausal monkey model. They first selected out a high-estrogen group of monkeys and a low-estrogen group. Next, they fed each group four different diets for 16 weeks each, along with a high or a low dose of estrogen.
The diets included either no isoflavones; 60 milligrams of isoflavones (similar to the typical Asian diet); 120 milligrams (highest amount that can be obtained via diet alone); or 240 milligrams (levels that must be obtained via supplements).
Next, Wood’s team measured how the diets affected so-called “markers” for breast cancer risk, such as breast cell proliferation.
“No effect of the isoflavones was seen in the low-estrogen animals,” he said.
In contrast, among the high-estrogen groups the researchers observed more breast cell proliferation when isoflavones were NOT added to the diet, and when they were added in smaller doses. High levels of the isoflavones tended to block the effect of estrogen on breast tissue in the high-estrogen animals. The strongest effects were seen at 240 milligrams daily, Wood said.
“In the postmenopausal period, women with high natural estrogen levels have higher breast cancer risk,” he said. So the isoflavones may help reduce risk in those who need it most. These women with high estrogen levels may get the most benefit from isoflavones in soy in terms of cancer risk reduction, Wood said.
“Isoflavones may connect with cell receptors normally reserved for estrogen,” he speculated, thus reducing the breast’s exposure to estrogen, thereby decreasing cancer risk.

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Slim Plan GoldTM Shake
Though its milkshake-like taste is the first thing customers mention, its real genius lies in its many nutritional benefits.

Wood stopped short of giving dietary advice, only noting that the topic warrants further study in humans.
Another expert praised the study and said it gives women reassurance. “This study is basically coming down on the side of, ‘Do not worry about the effect of estrogen on the breasts of postmenopausal women,”‘ said Mindy Kurzer, a professor of nutrition at the University of Minnesota, who has published on the topic of soy intake. “I think it’s an excellent study.”
The study does have its limitations, she said — most notably the fact that it was conducted in animals, not humans. However, “the monkey is the absolutely best animal model for this kind of study,” Kurzer said, because its physiology is so close to that of humans.
The finding that there was virtually no effect of soy in the low-estrogen group is also good news when it comes to breast cancer risk, she added. “The concern was that the phytoestrogens (isoflavones) might mimic estrogen when estrogen is not around.”
Soy is considered good for building bones and good for heart health, Kurzer said, as well as for relieving hot flashes during menopause.
Copyright 2006 The New York Times News Service. All rights reserved.

Oily fish makes babies brainier

Oily fish makes ‘babies brainier’
Eating oily fish and seeds in pregnancy can boost children’s future brain power and social skills, research suggests.
A study of 9,000 mothers and children in Avon suggested those who consumed less of the essential fatty acid Omega-3 had children with lower IQs.

These children also had poorer motor skills and hand-to-eye co-ordination, research in the Economist said.

The Food Standards Agency says pregnant women should consume only one or two portions of oily fish a week.

A team from the National Institutes of Health in the US analysed data from a long-term study done in Avon, UK.


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‘Frightening data’

Looking at the effects of Omega-3 intake on 9,000 mothers and their children, the team found mothers with the lowest intake of the essential fatty acid had children with a verbal IQ six points lower than the average.

While those with the highest consumption of mackerel and sardines and other sources of Omega-3 had children, at age three-and-a-half, with the best measures of fine-motor performance, researchers said.

Low intake of the crucial fatty acid also appeared to lead to more problems of social interactions – such as an inability to make friends.

Research leader Dr Joseph Hibbeln said “frightening data” showed 14% of 17-year-olds whose mother had eaten small quantities of Omega -3 during pregnancy demonstrated this sort of behaviour.

This compared with 8% of those born to the group with the highest intake, he said.

Dr Hibbeln said: “The findings of poor social development and poor motor control in children indicate that these children may be on a developmental trajectory towards lifelong disruptive and poorly-socialised behaviour as they grow up.”

It’s absolutely essential that pregnant women take in enough Omega-3 and that children in early infancy take in enough Omega-3
Patrick Holford
Nutritional expert


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Omega Guard™ provides a full spectrum of seven natural omega 3 fatty acids — EPA, DHA, ALA and more for cardiovascular health and to support healthy vision, brain and joint function

Professor Jean Golding of Bristol University set up the original research – the Avon Longitudinal Study of Parents and Children -15 years ago to look at the predisposition to disease.She told the BBC: “The baby’s brain needs Omega-3 fatty acids. It doesn’t create its own fatty acids so it needs to be something that the mother will eat.”

The new research also builds on earlier work in the US which suggests pregnant mothers will develop children with better language and communication skills if they regularly consume oily fish.

Nutritional expert Patrick Holford, director of the Brain Bio Centre, said Omega-3 was key to children’s intelligence because the brain is formed of 60% fat – 30% of which is essential fats.

Successive studies have shown clear links between intelligence and consumption of this essential fatty acid, he added.

Seed option

“It’s absolutely essential that pregnant women take in enough Omega-3 and that children in early infancy take in enough Omega-3.”

The richest sources of Omega-3 are larger fish which eat other fish, but research shows that the larger the fish the more pollutants, such as mercury, they contain.

For this reason Mr Holford recommends women consume two portions of wild or organic salmon, trout or sardines weekly.

Seeds such as flax, pumpkin and hemp are good sources of Omega-3 for vegetarians, but large quantities need to be consumed to gain the same effect.

This might translate to two tablespoons of seeds daily, Mr Holford said, but women can also use a high quality Omega-3 supplements.

Story from BBC NEWS:


World’s Finest Fish oil
Omega Guard™ provides a full spectrum of seven natural omega 3 fatty acids — EPA, DHA, ALA and more for cardiovascular health and to support healthy vision, brain and joint function